Orthopedic Stem Cell Therapy

For Painful Joint Conditions and Injuries

Orthopedic Stem Cell Therapy Overview

Orthopedics is the field of medicine concerned with the study and treatment of the musculoskeletal system; our joints, muscles and spine. And Mesenchymal Stem Cells are the specific type of stem cells within our body that replicate and differentiate into the bone, cartilage, connective tissues and muscles cells that make up our musculoskeletal system. The orthopedic stem cell therapy that we provide at Pangenics Regenerative Center is a safe, minimally-invasive procedure where we harvest millions of mesenchymal stem cells from a small amount your body’s adipose tissue, (body fat), then inject them directly into damaged or injured joints and via IV so they can work to repair the damaged cells in the joint. The following is a more detailed explanation of the orthopedic stem cell therapy available at Pangenics Regenerative Center.

Orthopedic Stem Cell Therapy in Jacksonville Florida

What Are Mesenchymal Stem Cells and How Do They Work

Adult Mesenchymal Stem Cell

Adult Mesenchymal
Stem Cell

When it comes to improving joint pain and healing joint injuries, mesenchymal stem cells are the right stem cells for the job. Mesenchymal stem cells are the type of stem cells that replicate and differentiate into bone, cartilage, connective tissue, and muscle cells. They reside in many areas throughout our body until called upon by damaged joint cells using a messaging system called paracrine signaling. They respond to the damaged joint cells and begin to replicate and differentiate into bone, cartilage, connective tissue and muscle performing our body’s amazing ability to heal itself.

So, why do we develop persistent joint pain and joint injuries that never seem to completely heal? The answer to this question is similar to many other health related questions. It has to do with our age. The older we get, the fewer mesenchymal stem cells we have, which is one of the reasons our joints don’t heal as fast as they did when we were young. Another reason is the conditions with our body where mesenchymal stem cells reside and the condition of the mesenchymal stem cells themselves can slow their ability to respond to damaged joint cells. Learn more about Mesenchymal Stem Cells.

How We Harvest Millions
of Your Live Mesenchymal Stem Cells

Now that we’ve explained mesenchymal stem cells and their valuable function of repairing joints by replicating and differentiating into bone, cartilage, connective tissue and muscle, the next question is how do we help them get to the joints where they are needed?

The first step in orthopedic stem cell therapy at Pangenics Regenerative Center is much different than most other stem cell therapy centers. While most centers today opt for either harvesting mesenchymal stem cells from bone marrow, which yields less than 10,000 viable cells per 2 ounces of bone marrow, or purchasing frozen umbilical cord cells that can lead to possible genetic and epigenetic changes, and low cell survival rates. Pangenics stem cell physicians harvest millions of live viable mesenchymal stem cells from adipose tissue, (body fat).

Our extensive research and the hundreds of physicians that participate with us in national IRBs, (Institutional Review Boards) have repeatedly verified that harvesting mesenchymal stem cells from adipose tissue, (body fat) allows for the collection of 10s of millions of live viable mesenchymal stem cells.

Our particular process is a 38 step process that allows us to harvest up to 50 million live, viable mesenchymal stem cells. Millions more than can be harvested from bone marrow, and that have a much higher survival rate because they are transferred from one area of the body to the area of therapy and not frozen and thawed.

We begin orthopedic stem cell therapy by collecting a small amount of body fat using a closed sterile, FDA approved fat collection system called Adivive®. This allows us to harvest what we refer to as SVF or Stromal Vascular Fraction.

Stromal Vascular Fraction, SVF Explained

Stromal: Best explained as a pinch of fat. The first layer of fat directly beneath the skin.

Vascular: Within the Stromal fat, there are tiny blood vessels where mesenchymal stem cells are found in abundance.

Fraction: The heterogeneous group of cells derived from the fat that contains mesenchymal progenitor/stem cells, preadipocytes, endothelial cells, pericytes, T cells, and M2 macrophages.

The SVF then goes through all the remaining steps that purify and isolate the mesenchymal stem cells. Once the mesenchymal stem cells are completely separated from the stromal vascular fraction, a NucleoCounter® Cell Counter is used to count the viable, live mesenchymal stem cells to assure needed quantities are present. The Magellan® Autologous Platelet Separator is then used to filter platelets and seven different growth factors from a small amount of the patient’s blood. This produces Platelet Rich Plasma, (PRP). The Patient’s PRP and mesenchymal stem cells are combined. PRP is added to the stem cells to help them survive the transfer and maximize the effects of the therapy.

Magellen Platelet Separator

Magellen Platelet Separator

The Magellan Platelet Separator is used to produce platelet rich plasma, (PRP) from a small amount of the patient’s blood. The Magellan Platelet separator filters the blood to collect platelets and seven different growth factors from the patient’s blood which is them mixed with the patient’s mesenchymal stem cells. This step helps the mesenchymal stem cells survive, multiply and become replacement cells.

NucleoCounter NC-200 Cell Counter

NucleoCounter NC-200 Stem Cell Counter

The NucleoCounter Stem Cell Counter is used to identify the total number of live, viable mesenchymal stem cells before they are used in therapy. The exact number of live, viable stem cells harvested from each patient and used for their stem cell therapy is very important and is documented in the IRBs we participate in.

Millions of Live, Viable Mesenchymal Stem Cells Verified

The mesenchymal stem cell count below is from a patient’s records. During this patient’s therapy, we successfully harvested over 17 million live mesenchymal stem cells from only 2 ounces of the patient’s body fat.

Viable Stem Cell Confirmation Counts

Stem Cell Therapy is Performed

The final stage of mesenchymal stem cell therapy for joint conditions can now be performed. Millions of your own live, viable mesenchymal stem cells have been collected and isolated. They have been counted to verify needed quantities, and they have been nourished with platelets and seven different growth factors, (PRP). Millions of your stem cells are now ready to do their job and are injected directly into the joints targeted for therapy and also administered intravenously to maximize the therapy. Once the injections and or IV has been administered, the therapy is complete. There are no side effects and patients are able to drive home or back to work shortly after their therapy.

What Our Patients Are Saying

Dr. Lewis J. Obi, Dr. Kenneth Eaddy and the experienced medical staff at Pangenics have been helping patients reduce and eliminate painful joint and back conditions, breath easier and get back to doing the things they enjoy for over 15 years. And many of their patients share their stories about how the stem cell therapy they received at Pangenics gave them their life back and allowed them to avoid invasive surgery. Hear how stem cell therapy eliminated this patient’s knee and hip problems.

More Stem Cell Patient Reviews

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