Stem Cell Therapy

How Millions of Your Own Live Mesenchymal Stem Cells Can Improve Painful Joint and Spine Conditions

We believe that if a therapy is available and safe, it should be easily accessible and available to those who may benefit from it. In our case, it’s mesenchymal stem cell therapy. And we have documented IRB therapy results of how it has helped thousands of people. Today we are able to harvest tens of millions of your own adult stem cells and use them as a therapy to improve joint pain caused by arthritic conditions and injuries, improve spinal conditions and injuries. Mesenchymal stem cells have also allowed Dr. Obi to reduce the invasiveness of plastic surgery and improve recovery times.

What Are Mesenchymal Stem Cells and How Do They Work

Adult Mesenchymal Stem Cell

Adult Mesenchymal
Stem Cell

Mesenchymal stem cells are one of the many types of stem cells that we are born with. And like all types of stem cells, they serve as one of the body’s key healing tools by replicating and differentiating into various cell types. Mesenchymal stem cells replicate and differentiate into bone, cartilage, connective tissue, muscle, and fat cells. Mesenchymal stem cells reside in areas throughout our bodies waiting to be called upon to replace damaged cells. When our body’s bone, cartilage, connective tissue, muscle, or fat cells are damaged or injured, they use a messaging system called paracrine signaling to call for help. Mesenchymal stem cells respond to these signals from injured and damaged cells, and repair and replace the damages cells as part of the body’s healing process. Learn more about Mesenchymal Stem Cells.

How Mesenchymal Stem Cell Therapy Works

It is estimated that we are born with around sextillion mesenchymal stem cells. That’s 1,000,000,000,000,000,000,000. Which is why children don’t generally experience persistent joint pain and back pain or develop COPD. And it’s also why younger people heal to their original condition after injuries much faster than older people. By age 50, we have about half of our mesenchymal stem cells, right around the time in our lives when we start experiencing the effects of “aging” or the effects of damage we either did to ourselves or from an accidental injury. It takes our bones, cartilage, connective tissues, muscles, or fat either longer to heal or not heal as we age because we have fewer and fewer mesenchymal stem cells. And the one’s we have left become less and less responsive over time to the body’s paracrine signaling system. Stem cell therapy replaces and expedites our body’s ability to race millions of mesenchymal stem cells to damaged or injured bones, cartilage, connective tissues, muscles and fat by harvesting millions of a patient’s own mesenchymal stem cells, concentrating and enriching them, and introducing them directly to the therapy area and also intravenously. Mesenchymal stem cell therapy is simply helping the body’s own mesenchymal stem cells get to where they are needed.

Stem Cell Therapies for Knees

How Mesenchymal Stem Cell Therapy Works

Stem Cell Therapies for Knees

It is estimated that we are born with around sextillion mesenchymal stem cells. That’s 1,000,000,000,000,000,000,000. Which is why children don’t generally experience persistent joint pain and back pain or develop COPD. And it’s also why younger people heal to their original condition after injuries much faster than older people. By age 50, we have about half of our mesenchymal stem cells, right around the time in our lives when we start experiencing the effects of “aging” or the effects of damage we either did to ourselves or from an accidental injury. It takes our bones, cartilage, connective tissues, muscles, or fat either longer to heal or not heal as we age because we have fewer and fewer mesenchymal stem cells. And the one’s we have left become less and less responsive over time to the body’s paracrine signaling system. Stem cell therapy replaces and expedites our body’s ability to race millions of mesenchymal stem cells to damaged or injured bones, cartilage, connective tissues, muscles and fat by harvesting millions of a patient’s own mesenchymal stem cells, concentrating and enriching them, and introducing them directly to the therapy area and also intravenously. Mesenchymal stem cell therapy is simply helping the body’s own mesenchymal stem cells get to where they are needed.

How We Harvest Millions
of Your Live Mesenchymal Stem Cells

Dr. Lewis J. Obi supervising SVF preparation

Many stem cell therapy providers still harvest mesenchymal stem cells from bone marrow which involves drilling a hole usually in the patient’s hip bone and using a syringe to extract bone marrow. Most of the stem cells found in bone marrow are hematopoietic stem cells that become red blood cells, platelets, or white blood cells. Mesenchymal stem cell counts in bone marrow are less than 10,000 per 2 ounces of bone marrow.

Purchasing and using cryopreserved, (frozen) umbilical cord stem cells is another popular option with many stem cell therapy providers. However, there are numerous undesirable aspects of cryopreservation that lead to possible genetic and epigenetic changes, and low cell survival rates.

At Pangenics Regenerative Center our stem cell physicians use a 38-step process to harvest up to 50 million live mesenchymal stem cells from a patient’s adipose tissue, (body fat), isolate and enrich the harvested cells with platelet rich plasma, and then injecting live, viable mesenchymal stem cells directly into the damaged joint and also intravenously.

Therapy begins with a small amount of body fat that is collected with the Adivive FDA approved fat transfer system under local anesthetic. In this first step we collect adipose tissue, (fat) that is rich with mesenchymal stem cells and retrieve what we refer to as Stromal Vascular fraction, (SVF):

Stromal Vascular Fraction, SVF Explained

Stromal: Best explained as a pinch of fat. The first layer of fat directly beneath the skin.

Vascular: Within the Stromal fat, there are tiny blood vessels where mesenchymal stem cells are found in abundance.

Fraction: The heterogeneous group of cells derived from the fat that contains mesenchymal progenitor/stem cells, preadipocytes, endothelial cells, pericytes, T cells, and M2 macrophages.

The SVF then goes through all the remaining steps that purify and isolate the mesenchymal stem cells. Once the mesenchymal stem cells are completely separated from the stromal vascular fraction, a NucleoCounter® Cell Counter is used to count the viable, live mesenchymal stem cells to assure needed quantities are present. The Magellan® Autologous Platelet Separator is then used to filter platelets and seven different growth factors from a small amount of the patient’s blood. This produces Platelet Rich Plasma, (PRP). The Patient’s PRP and mesenchymal stem cells are combined. PRP is added to the stem cells to help them survive the transfer and maximize the effects of the therapy.

Magellen Platelet Separator

Magellen Platelet Separator

The Magellan Platelet Separator is used to produce platelet rich plasma, (PRP) from a small amount of the patient’s blood. The Magellan Platelet separator filters the blood to collect platelets and seven different growth factors from the patient’s blood which is them mixed with the patient’s mesenchymal stem cells. This step helps the mesenchymal stem cells survive, multiply and become replacement cells.

NucleoCounter NC-200 Cell Counter

NucleoCounter NC-200 Stem Cell Counter

The NucleoCounter Stem Cell Counter is used identify the total number of Live, Viable Mesenchymal Stem Cells before they are used in therapy. The exact number of live, viable stem cells harvested from each patient and used for their stem cell therapy is very important and is documented in the IRBs we are participating in.

Millions of Live, Viable Mesenchymal Stem Cells Verified

The mesenchymal stem cell count below is from a patient’s records. During this patient’s therapy, we successfully harvested over 17 million live mesenchymal stem cells from only 2 ounces of the patient’s body fat.

Viable Stem Cell Confirmation Counts

The final step of stem cell therapy can now be performed. Millions of your own live, viable mesenchymal stem cells have been collected and isolated. They have been counted to verify needed quantities, and they have been nourished with platelets and seven different growth factors, (PRP). Millions of your stem cells are now ready to do their job and are injected directly into the joints targeted for therapy and also administered intravenously to maximize the therapy. Once the injections and or IV has been administered, the therapy is complete. There are no side effects and patients are able to drive home or back to work shortly after their therapy.

Safety is Our Primary Concern

Stem Cell Therapy is performed within our state licensed ambulatory surgical center and patient safety is of our utmost concern. In our history, not a single patient has experienced an adverse reaction to the types of stem cell therapies we provide at Pangenics Regenerative Center.

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